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Time-dependent lethal body residues for the toxicity of pentachlorobenzene to Hyalella azteca

Environmental Toxicology and Chemistry

By:
, , , , , , ,

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Abstract

The study examined the temporal response of Hyalella azteca to pentachlorobenzene (PCBZ) in water-only exposures. Toxicity was evaluated by calculating the body residue of PCBZ associated with survival. The concentration of PCBZ in the tissues of H. azteca associated with 50% mortality decreased from 3 to 0.5 I?mol/g over the temporal range of 1 to 28 d, respectively. No significant difference was observed in the body residue calculated for 50% mortality when the value was determined using live or dead organisms. Metabolism of PCBZ was not responsible for the temporal response because no detectable PCBZ biotransformation occurred over an exposure period of 10 d. A damage assessment model was used to evaluate the impact and repair of damage by PCBZ on H. azteca. The toxicokinetics were determined so that the temporal toxicity data could be fit to a damage assessment model. The half-life calculated for the elimination of PCBZ averaged approximately 49 h, while the value determined for the half- life of damage repair from the damage assessment model was 33 h.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Time-dependent lethal body residues for the toxicity of pentachlorobenzene to Hyalella azteca
Series title:
Environmental Toxicology and Chemistry
Volume
23
Issue:
5
Year Published:
2004
Language:
English
Contributing office(s):
Great Lakes Science Center
Description:
p. 1335-1343
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
First page:
1335
Last page:
1343
Number of Pages:
8