Determination of benzocaine in rainbow trout plasma
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Abstract
A liquid chromatographic method is described for analysis of benzocaine (BZ), a proposed fish anesthetic, in rainbow trout plasma. Mean recoveries of BZ from plasma samples fortified at 44–10 100 ng/mL were 96–100%. The method detection limit is 10 ng/mL, and the limit of quantitation is 37 ng/mL. Acetylation of BZ occurs in whole blood after storage at room temperature (i.e., 21 °C) for 10 min. However, no acetylation of BZ was detected in plasma samples held at room temperature for 4 h. Mean method precision for plasma samples with incurred BZ residue is similar to that for fortified samples in the same concentration range (relative standard deviations of 0.9 and 1.2%, respectively).
Publication type | Article |
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Publication Subtype | Journal Article |
Title | Determination of benzocaine in rainbow trout plasma |
Series title | Journal of AOAC International |
DOI | 10.1093/jaoac/79.3.623 |
Volume | 79 |
Issue | 3 |
Year Published | 1996 |
Language | English |
Publisher | Oxford Academic |
Contributing office(s) | Upper Midwest Environmental Sciences Center |
Description | 5 p. |
First page | 623 |
Last page | 627 |
Google Analytic Metrics | Metrics page |