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Liquid chromatographic determination of florfenicol in the plasma of multiple species of fish

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

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Abstract

A simple method was developed for determining florfenicol concentration in a small volume (250 mul) of plasma from five phylogenetically diverse species of freshwater fish. Florfenicol was isolated from the plasma matrix through C-18 solid-phase extraction and quantified by reversed-phase high-performance liquid chromatography with UV detection. The accuracy (84-104%), precision (%RSDless than or equal to8), and sensitivity (quantitation limit <30 ng/ml) of the method indicate its usefulness for conducting pharmacokinetic studies on a variety of freshwater fish. Published by Elsevier Science B.V.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Liquid chromatographic determination of florfenicol in the plasma of multiple species of fish
Series title:
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume
780
Issue:
1
Year Published:
2002
Language:
English
Publisher:
U.S. Geological Survey
Contributing office(s):
Upper Midwest Environmental Sciences Center
Description:
pp. 111-117
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
First page:
111
Last page:
117
Number of Pages:
7