Turnover and urinary excretion of free and acetylated MS-222 rainbow trout, Salmo gairdneri

Hunn, J. B.; Schoettger, R. A.; Willford, W. A.

Abstract:

Rainbow trout (Salmo gairdneri) anesthetized in 100 mg/liter of M.S. 222 at 12 C excreted the drug in free and acetylated forms via the urine during a 24-hr recovery period in freshwater. Of the M.S. 222 excreted, 77-96% was acetylated. Blood levels of free drug in anesthetized trout approximated 75% of the anesthetic concentration, but the amount of acetylated M.S. 222 was relatively insignificant. The blood and urine were cleared of the two fractions of M.S. 222 in 8 and 24 hr respectively. Low levels of aromatic amines of natural origin occurred in blood and urine and were subtracted from measurements of M.S. 222. Intraperitoneal injections of 10-100 mg/kg of M.S. 222 did not induce anesthesia; however, the 24-hr pattern of drug excretion was similar to that observed after anesthesia by immersion. Only 15-21 % of the injected dose was found in the urine, suggesting a second route of drug elimination.

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Article

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1003267

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Hunn, J. B.; Schoettger, R. A.; Willford, W. A.

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Upper Midwest Environmental Sciences Center

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English

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Journal of the Fisheries Research Board of Canada

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pp. 25-31

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Turnover and urinary excretion of free and acetylated MS-222 rainbow trout, Salmo gairdneri; 1968; Article; Journal; Journal of the Fisheries Research Board of Canada; Hunn, J. B.; Schoettger, R. A.; Willford, W. A.