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Metabolism and elimination of benzocaine by rainbow-trout, Oncorhynchus mykiss

Xenobiotica

By:
, , and
DOI: 10.3109/00498259109039492

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Abstract

1. Branchial and urinary elimination of benzocaine residues was evaluated in adult rainbow trout, oncorhynchus mykiss, given a single dorsal aortic dose of c-14-benzocaine hydrochloride.^2. Branchial elimination of benzocaine residues was rapid and accounted for 59.2% Of the dose during the first 3 h after dosing. Renal elimination of radioactivity was considerably slower; the kidney excreted 2.7% Dose within 3 h and 9.0% Within 24 h. Gallbladder bile contained 2.0% Dose 24 h after injection.^3. Of the radioactivity in radiochromatograms from water taken 3 min after injection, 87.3% Was benzocaine and 12.7% Was n-acetylated benzocaine. After 60 min, 32.7% Was benzocaine and 67.3% Was n-acetylated benzocaine.^4. Of the radioactivity in radiochromatograms from urine taken 1 h after dosing, 7.6% Was para-aminobenzoic acid, 59.7% Was n-acetylated para-aminobenzoic acid, 19.5% Was benzocaine, and 8.0% Was n-acetylated benzocaine. The proportion of the radioactivity in urine changed with time so that by 20 h, 1.0% Was para-aminobenzoic acid and 96.6% Was n-acetylated para-aminobenzoic acid.^5. Benzocaine and a more hydrophobic metabolite, n-acetylated benzocaine, were eliminated primarily through the gills; renal and biliary pathways were less significant elimination routes for benzocaine residues.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Metabolism and elimination of benzocaine by rainbow-trout, Oncorhynchus mykiss
Series title:
Xenobiotica
DOI:
10.3109/00498259109039492
Volume
21
Issue:
4
Year Published:
1991
Language:
English
Publisher:
University of Wisconsin; U.S. Fish and Wildlife Service
Contributing office(s):
Upper Midwest Environmental Sciences Center
Description:
pp. 525-533
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Xenobiotica
First page:
525
Last page:
533
Number of Pages:
9