| Abstract: | The pharmacokinetics, tissue distribution, and metabolism of 1-naphthol were examined in the channel catfish (Ictalurus punctatus ). After oral dosing, peak plasma concentrations of 1-naphthol occurred at 1 hr; parent compound made up less than 15% of the total radioactivity, and the bioavailability was 32%. Plasma protein binding was 92% and was independent of concentration. 1-Naphthol and metabolites were rapidly eliminated from the tissues after oral dosing. |
| Genre: | Article |
| ProdID: | 1003526 |
| Citation Author: | Stehly, G. R.; Plakas, S. M. |
| Citation Contributing Office: | Upper Midwest Environmental Sciences Center |
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| Citation End Page: | 73 |
| Citation Issue: | 1 |
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| Citation Language: | English |
| Citation Larger Work Title: | Drug Metabolism and Disposition |
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| Citation Number Of Pages: | 4 |
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| Citation Phsyical Description: | pp. 70-73 |
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| Citation Publisher: | U.S. Food and Drug Administration |
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| Citation Search Results Text: | Disposition of 1-naphthol in the channel catfish (Ictalurus punctatus); 1992; Article; Journal; Drug Metabolism and Disposition; Stehly, G. R.; Plakas, S. M. |
| Citation Start Page: | 70 |
| Citation Volume: | 20 |
| Citation Year: | 1992 |
| Type: | citation/reference |
| Text: | Disposition of 1-naphthol in the channel catfish (Ictalurus punctatus); 1992; Article; Journal; Drug Metabolism and Disposition; Stehly, G. R.; Plakas, S. M. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| Date Other: | Wed, 1 Jan 1992 00:00 -0600 |
| Publisher: | U.S. Food and Drug Administration |
