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Pharmacokinetic modeling in aquatic animals. 1. Models and concepts

Aquatic Toxicology

By:
, , and

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Abstract

While clinical and toxicological applications of pharmacokinetics have continued to evolve both conceptually and experimentally, pharmacokinetics modeling in aquatic animals has not progressed accordingly. In this paper we present methods and concepts of pharmacokinetic modeling in aquatic animals using multicompartmental, clearance-based, non-compartmental and physiologically-based pharmacokinetic models. These models should be considered as alternatives to traditional approaches, which assume that the animal acts as a single homogeneous compartment based on apparent monoexponential elimination.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Pharmacokinetic modeling in aquatic animals. 1. Models and concepts
Series title:
Aquatic Toxicology
Volume
17
Issue:
3
Year Published:
1990
Language:
English
Contributing office(s):
Upper Midwest Environmental Sciences Center
Description:
pp. 187-212
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Aquatic Toxicology
First page:
187
Last page:
212
Number of Pages:
26