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Disposition of pentachlorophenol in rainbow trout (Salmo gairdneri ): Effect of inhibition of metabolism

Aquatic Toxicology

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Abstract

The accumulation kinetics of pentachlorophenol (PCP) were investigated in rainbow trout (Salmo gairdneri ) in the absence and presence of 25 mg/l salicylamide, an inhibitor of PCP metabolism. After exposure to 5 mu g/l PCP over 1-96 h, the amount of PCP in the whole fish, its concentration in water and the total amount of metabolites (water, whole fish and bile) were measured. Equations for these variables, based on a two compartment pharmacokinetic model, were fitted simultaneously to the data using the computer program NONLIN, which uses an iterative nonlinear least squares technique. Salicylamide decreased the metabolic clearance of PCP, which resulted in an increase in the bioconcentration factor (BCF); this increase was partially offset by a salicylamide-induced decrease in the apparent volume of distribution of PCP. A clearance-volume compartment model permitted partitioning of the BCF in terms of the underlying physiologic and biochemical processes (uptake clearance, metabolic clearance and apparent volume of distribution).

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Disposition of pentachlorophenol in rainbow trout (Salmo gairdneri ): Effect of inhibition of metabolism
Series title:
Aquatic Toxicology
Volume
14
Issue:
2
Year Published:
1989
Language:
English
Publisher:
Great Lakes Environ. Res. Lab., NOAA
Contributing office(s):
Upper Midwest Environmental Sciences Center
Description:
pp. 131-148
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Aquatic Toxicology
First page:
131
Last page:
148
Number of Pages:
18