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The potential role of natural tumor promoters in marine turtle fibropapillomatosis

Journal of Aquatic Animal Health

By:
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Abstract

Fibropapillomatosis (FP) in green turtles Chelonia mydas is a debilitating, neoplastic disease that has reached worldwide epizootic levels. The etiology of FP is unknown but has been linked to oncogenic viruses. Toxic benthic dinoflagellates (Prorocentrum spp.) are not typically considered tumorigenic agents, yet they have a worldwide distribution and produce a tumor promoter, okadaic acid (OA). Prorocentrum spp. are epiphytic on macroalgae and seagrasses that are normal components of green turtle diets. Here we show that green turtles in the Hawaiian Islands consume Prorocentrum and that high-risk FP areas are associated with areas where P. lima and P. concavum are both highly prevalent and abundant. The presence of presumptive OA in the tissues of Hawaiian green turtles further suggests exposure and a potential role for this tumor promoter in the etiology of FP.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
The potential role of natural tumor promoters in marine turtle fibropapillomatosis
Series title:
Journal of Aquatic Animal Health
Volume
11
Issue:
3
Year Published:
1999
Language:
English
Contributing office(s):
National Wildlife Health Center
Description:
p. 199-210
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
First page:
199
Last page:
210
Number of Pages:
12