| Abstract: | Spontaneous mastocytomas studied in 18 axolotls (Ambystoma mexicanum) and six tiger salamanders (Ambystoma tigrinum) were gray-white, uni- to multilobular cutaneous protrusions from 2mm to 2cm in diameter. Tumors were moderately cellular unencapsulated masses that usually infiltrated the dermis and hypodermis with the destruction of intervening tissues. Some tumors were invading superficial bundles of the underlying skeletal muscle. Tumors consisted of mitotically active cells derived from a single lineage but showing a range of differentiation. Immature cells had nearly smooth to lightly cleft or folded basophilic nuclei bordered by a band of cytoplasm with few cytoplasmic processes and containing a few small uniform eccentric granules. Mature cells had basophilic nuclei with deep clefts or folds and abundant eosinophilic cytoplasm with multiple long intertwining cytoplasmic extensions packed with metachromatic granules. The axolotls were old individuals from an inbred laboratory colony. The tiger salamanders were wild animals from a single polluted pond. They could have been old and inbred. Both groups were neotenic. These are the first mastocytomas discovered in cold-blooded animals. |
| Genre: | Article |
| ProdID: | 1003937 |
| Citation Author: | Harshbarger, J. C.; Chang, S. C.; DeLanney, L. E.; Rose, F. L.; Green, D. E. |
| Citation Contributing Office: | National Wildlife Health Center |
| Citation Datum: | |
| Citation Day: | |
| Citation Edition: | |
| Citation Editor: | |
| Citation End Page: | 192 |
| Citation Issue: | 3-4 |
| Citation Keywords: | |
| Citation Language: | English |
| Citation Larger Work Title: | Journal of Cancer Research and Clinical Oncology |
| Citation LatN: | |
| Citation LatS: | |
| Citation LonE: | |
| Citation LonW: | |
| Citation Month: | |
| Citation No Pagination: | |
| Citation Number Of Pages: | 6 |
| Citation Online Only Flag: | |
| Citation Phsyical Description: | p. 187-192 |
| Citation Projection: | |
| Citation Public Comments: | |
| Citation Publisher: | |
| Citation Series: | |
| Citation Series Code: | |
| Citation Series Number: | |
| Citation Search Results Text: | Cutaneous mastocytomas in the neotenic caudate amphibians Ambystoma mexicanum (axolotl) and Ambystoma tigrinun (tiger salamander); 1999; Article; Journal; Journal of Cancer Research and Clinical Oncology; Harshbarger, J. C.; Chang, S. C.; DeLanney, L. E.; Rose, F. L.; Green, D. E. |
| Citation Start Page: | 187 |
| Citation Volume: | 125 |
| Citation Year: | 1999 |
| Type: | citation/reference |
| Text: | Cutaneous mastocytomas in the neotenic caudate amphibians Ambystoma mexicanum (axolotl) and Ambystoma tigrinun (tiger salamander); 1999; Article; Journal; Journal of Cancer Research and Clinical Oncology; Harshbarger, J. C.; Chang, S. C.; DeLanney, L. E.; Rose, F. L.; Green, D. E. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| URL (INDEX PAGE): | http://www.springerlink.com/content/tevda22gtq5qy63y/ |
| Date Other: | Fri, 1 Jan 1999 00:00 -0600 |
| Publisher: | |
