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A receptor binding assay applied to monitoring the neurotoxicity of parathion to Peromyscus after oral exposure

OCLC: 29694316
By:
, ,
DOI: 10.1520/STP13159S

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Abstract

Many naturally occurring toxins, as well as pesticides, metals, and other compounds that occur in our environment from anthropogenic activities, stimulate or antagonize neuro-receptors to produce acute and/or chronic toxicities. Recent advances in laboratory instrumentation and the availability of a variety of radiolabeled ligands and type-specific drugs for numerous receptors make it possible to easily screen large numbers of samples and detect changes in sensitivity and density of receptor types and subtypes. A receptor binding assay for examining the chronic dietary toxicity of parathion will be used as a model to describe the methodology.

Additional Publication Details

Publication type:
Book chapter
Publication Subtype:
Book Chapter
Title:
A receptor binding assay applied to monitoring the neurotoxicity of parathion to Peromyscus after oral exposure
Series number:
1216
DOI:
10.1520/STP13159S
Year Published:
1993
Language:
English
Publisher:
American Society for Testing and Materials
Publisher location:
Philadelphia, Pennsylvania
Contributing office(s):
Patuxent Wildlife Research Center
Description:
xii+730
Larger Work Type:
Book
Larger Work Subtype:
Other Government Series
Larger Work Title:
Environmental toxicology and risk assessment, 2nd volume; Symposium on Environmental Toxicology and Risk Assessment: Aquatic, Plant, and Terrestrial, Pittsburgh, Pennsylvania, USA, April 26-30, 1992
First page:
253
Last page:
262