A receptor binding assay applied to monitoring the neurotoxicity of parathion to Peromyscus after oral exposure
OCLC: 29694316
By: David A. Jett, A.T. Eldefrawi, and M.E. Eldefrawi
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Abstract
Many naturally occurring toxins, as well as pesticides, metals, and other compounds that occur in our environment from anthropogenic activities, stimulate or antagonize neuro-receptors to produce acute and/or chronic toxicities. Recent advances in laboratory instrumentation and the availability of a variety of radiolabeled ligands and type-specific drugs for numerous receptors make it possible to easily screen large numbers of samples and detect changes in sensitivity and density of receptor types and subtypes. A receptor binding assay for examining the chronic dietary toxicity of parathion will be used as a model to describe the methodology.
| Publication type | Book chapter |
|---|---|
| Publication Subtype | Book Chapter |
| Title | A receptor binding assay applied to monitoring the neurotoxicity of parathion to Peromyscus after oral exposure |
| Series number | 1216 |
| DOI | 10.1520/STP13159S |
| Year Published | 1993 |
| Language | English |
| Publisher | American Society for Testing and Materials |
| Publisher location | Philadelphia, Pennsylvania |
| Contributing office(s) | Patuxent Wildlife Research Center |
| Description | xii+730 |
| Larger Work Type | Book |
| Larger Work Subtype | Other Government Series |
| Larger Work Title | Environmental toxicology and risk assessment, 2nd volume; Symposium on Environmental Toxicology and Risk Assessment: Aquatic, Plant, and Terrestrial, Pittsburgh, Pennsylvania, USA, April 26-30, 1992 |
| First page | 253 |
| Last page | 262 |
| Google Analytic Metrics | Metrics page |