| Abstract: | The antibiotic actidione was found to be highly repellent to laboratory rats and to significantly reduce gnawing attacks upon treated paperboards. Rats refused to accept food or water containing this material even under conditions of acute starvation and died of starvation and thirst,rather than accept water containing l.0 mg. of actidione per liter. The compound is highly toxic to .rats with the minimum .lethal dose by oral administration being approximately l.0 mg./Kg body weight. Paperboard treated with the compound resisted gnawing attacks by specially trained and motivated rats for periods of two hundred hours, although similar .untreated boards were pierced within thirty-to sixty minutes. |
| Genre: | Article |
| ProdID: | 5220061 |
| Citation Author: | Traub, R.; DeWitt, J.B.; Welch, J.F.; Newman, D. |
| Citation Contributing Office: | Patuxent Wildlife Research Center |
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| Citation End Page: | 555 |
| Citation Issue: | 10 |
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| Citation Language: | English |
| Citation Larger Work Title: | Journal of the American Pharmaceutical Association, Scientific Edition |
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| Citation Number Of Pages: | 4 |
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| Citation Phsyical Description: | 552-555 |
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| Citation Search Results Text: | Toxicity and repellency to rats of actidione; 1950; Article; Journal; Journal of the American Pharmaceutical Association, Scientific Edition; Traub, R.; DeWitt, J.B.; Welch, J.F.; Newman, D. |
| Citation Start Page: | 552 |
| Citation Volume: | 39 |
| Citation Year: | 1950 |
| Type: | citation/reference |
| Text: | Toxicity and repellency to rats of actidione; 1950; Article; Journal; Journal of the American Pharmaceutical Association, Scientific Edition; Traub, R.; DeWitt, J.B.; Welch, J.F.; Newman, D. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| Date Other: | Wed, 16 Jun 2010 12:18 -0500 |
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