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Toxicity and repellency to rats of actidione

Journal of the American Pharmaceutical Association, Scientific Edition

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Abstract

The antibiotic actidione was found to be highly repellent to laboratory rats and to significantly reduce gnawing attacks upon treated paperboards. Rats refused to accept food or water containing this material even under conditions of acute starvation and died of starvation and thirst,rather than accept water containing l.0 mg. of actidione per liter. The compound is highly toxic to .rats with the minimum .lethal dose by oral administration being approximately l.0 mg./Kg body weight. Paperboard treated with the compound resisted gnawing attacks by specially trained and motivated rats for periods of two hundred hours, although similar .untreated boards were pierced within thirty-to sixty minutes.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Toxicity and repellency to rats of actidione
Series title:
Journal of the American Pharmaceutical Association, Scientific Edition
Volume
39
Issue:
10
Year Published:
1950
Language:
English
Contributing office(s):
Patuxent Wildlife Research Center
Description:
552-555
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Journal of the American Pharmaceutical Association, Scientific Edition
First page:
552
Last page:
555
Number of Pages:
4