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Antibody response of sandhill and whooping cranes to an eastern equine encephalitis virus vaccine

Journal of Wildlife Diseases

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Abstract

As a possible strategy to protect whooping cranes (Grus americana) from fatal eastern equine encephalitis (EEE) viral infection, studies were conducted to determine the immune response of this species and sandhill cranes (Grus canadensis) to a formalin-inactivated EEE viral vaccine. Viral-specific neutralizing antibody was elicited in both species after intramuscular (IM) vaccination. Subcutaneous and intravenous routes of vaccination failed to elicit detectable antibody in sandhill cranes. Among the IM vaccinated cranes, the immune response was characterized by nondetectable or low antibody titers that waned rapidly following primary exposure to the vaccine. However, one or more booster doses consistently elicited detectable antibody and/or increased antibody titers in the whooping cranes. In contrast, cranes with pre-existing EEE viral antibody, apparently induced by natural infection, exhibited a rapid increase and sustained high-antibody titers. Even though EEE virus vaccine induced neutralizing antibody and produced no adverse side effects, further studies will be required to determine the protective efficacy of the antibody.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Antibody response of sandhill and whooping cranes to an eastern equine encephalitis virus vaccine
Series title:
Journal of Wildlife Diseases
Volume
23
Issue:
4
Year Published:
1987
Language:
English
Contributing office(s):
Patuxent Wildlife Research Center
Description:
539-544
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Journal of Wildlife Diseases
First page:
539
Last page:
544