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Pharmacokinetics of gentamicin in blood plasma of quail, pheasants, and cranes

American Journal of Veterinary Research

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Abstract

Rate of appearance, peak concentration, and the biological half-life of gentamicin in the plasma of quail (Coturnix coturnix), pheasants (Phasianus colchicus), and cranes (Grus canadensis tabida) were studied. Gentamicin was given IM in doses of 5, 10, and 20 mg/kg of body weight. Peak plasma concentrations occurred earliest in the quail, latest in the cranes. The peak concentrations varied directly with the administered doses in all species. The biological half-life of gentamicin was 42 +/- 12 minutes in the quail, 75 +/- 15 minutes in the pheasants, and 165 +/- 37 minutes in the cranes. On the basis of the present data, dosage regimens for gentaminic of 5 mg/kg every 8 hours in pheasants and cranes, and 10 mg/kg every 6 hours in quail, would be expected to give constant plasma concentrations greater than 4.0 micrograms/ml.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Pharmacokinetics of gentamicin in blood plasma of quail, pheasants, and cranes
Series title:
American Journal of Veterinary Research
Volume
40
Issue:
6
Year Published:
1979
Language:
English
Contributing office(s):
Patuxent Wildlife Research Center
Description:
892-895
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
American Journal of Veterinary Research
First page:
892
Last page:
895
Number of Pages:
4