| Abstract: | Rate of appearance, peak concentration, and the biological half-life of gentamicin in the plasma of quail (Coturnix coturnix), pheasants (Phasianus colchicus), and cranes (Grus canadensis tabida) were studied. Gentamicin was given IM in doses of 5, 10, and 20 mg/kg of body weight. Peak plasma concentrations occurred earliest in the quail, latest in the cranes. The peak concentrations varied directly with the administered doses in all species. The biological half-life of gentamicin was 42 +/- 12 minutes in the quail, 75 +/- 15 minutes in the pheasants, and 165 +/- 37 minutes in the cranes. On the basis of the present data, dosage regimens for gentaminic of 5 mg/kg every 8 hours in pheasants and cranes, and 10 mg/kg every 6 hours in quail, would be expected to give constant plasma concentrations greater than 4.0 micrograms/ml. |
| Genre: | Article |
| ProdID: | 5221180 |
| Citation Author: | Custer, R.S.; Bush, M.; Carpenter, J.W. |
| Citation Contributing Office: | Patuxent Wildlife Research Center |
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| Citation End Page: | 895 |
| Citation Issue: | 6 |
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| Citation Language: | English |
| Citation Larger Work Title: | American Journal of Veterinary Research |
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| Citation Number Of Pages: | 4 |
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| Citation Phsyical Description: | 892-895 |
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| Citation Search Results Text: | Pharmacokinetics of gentamicin in blood plasma of quail, pheasants, and cranes; 1979; Article; Journal; American Journal of Veterinary Research; Custer, R.S.; Bush, M.; Carpenter, J.W. |
| Citation Start Page: | 892 |
| Citation Volume: | 40 |
| Citation Year: | 1979 |
| Type: | citation/reference |
| Text: | Pharmacokinetics of gentamicin in blood plasma of quail, pheasants, and cranes; 1979; Article; Journal; American Journal of Veterinary Research; Custer, R.S.; Bush, M.; Carpenter, J.W. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| Date Other: | Wed, 16 Jun 2010 12:19 -0500 |
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