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Diabetes mellitus in a black-footed ferret

Journal of the American Veterinary Medical Association

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Abstract

Diabetes mellitus was tentatively diagnosed in a black-footed ferret with polyuria, polydipsia, polyphagia, dehydration, and weight loss. Laboratory findings (marked hyperglycemia (724 mg/100 ml), glycosuria, and ketonuria) and the subsequent favorable response to insulin therapy confirmed the diagnosis. Although lesions were not observed in the pancreas, gross and histologic findings concomitant with diabetes mellitus included arteriosclerosis, with calcification of the aorta and other major vessels; mild necrotizing hepatitis; and mild proliferative glomerulonephritis. A perineal adenocarcinoma, with metastasis to an internal iliac lymph node, was an incidental finding. Special stains demonstrated adequate numbers of beta cell granules in the islets of Langerhans. Thus, the diabetes was apparently due to a lack of release of the synthesized insulin or to diminished effectiveness of the secreted insulin.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Diabetes mellitus in a black-footed ferret
Series title:
Journal of the American Veterinary Medical Association
Volume
171
Issue:
9
Year Published:
1977
Language:
English
Contributing office(s):
Patuxent Wildlife Research Center
Description:
890-893
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Journal of the American Veterinary Medical Association
First page:
890
Last page:
893
Number of Pages:
4