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Depression of plasma luteinizing hormone concentration in quail by the anticholinesterase insecticide parathion

Comparative Biochemistry and Physiology, C

By:
, , and
DOI: 10.1016/0742-8413(86)90153-2

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Abstract

To examine the effects of parathion on basal plasma luteinizing hormone (LH) concentration, male Japanese quail (Coturnix japonica) were orally intubated with 0, 5 or 10 mg/kg parathion and sacrificed after 4, 8 and 24 hr. At the 5 mg/kg dose, plasma LH levels were reduced at 4 and 8 hr, but returned to control values by 24 hr. Brain acetylcholinesterase activity was substantially reduced by 10 mg/kg parathion (52, 75 and 37% inhibition at 4, 8 and 24 hr, respectively) and plasma LH concentration remained depressed through the 24-hr period. These findings suggest that the organophosphorus insecticide parathion may alter plasma LH concentration in a manner which might impair reproductive activity, and provide indirect evidence for a cholinergic component in the regulation of LH secretion in quail.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Depression of plasma luteinizing hormone concentration in quail by the anticholinesterase insecticide parathion
Series title:
Comparative Biochemistry and Physiology, C
DOI:
10.1016/0742-8413(86)90153-2
Volume
83
Issue:
2
Year Published:
1986
Language:
English
Contributing office(s):
Patuxent Wildlife Research Center
Description:
451-453
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Comparative Biochemistry and Physiology, C
First page:
451
Last page:
453
Number of Pages:
3