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Dopamine and norepinephrine depletion in ring doves fed DDE, dieldrin, and Aroclor 1254

Toxicology and Applied Pharmacology

By:
, , and
DOI: 10.1016/0041-008X(80)90383-X

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Abstract

The levels of dopamine and norepinephrine were measured in one-half of the brain of ring doves fed a control diet or a diet containing 2, 20, or 200 ppm DDE; 1, 4, or 16 ppm dieldrin; or 1, 10, or 100 ppm Aroclor 1254. Levels of DDE, dieldrin, or Aroclor 1254 were determined in the other half of each brain. The intermediate and high levels of each chemical caused depletions in both neurotransmitters, and brain residues of each chemical were negatively correlated with levels of neurotransmitters. The highest concentrations of DDE, dieldrin, and Aroclor 1254 depressed averages of dopamine to 42.4, 41.4, and 45.2% of the control level and norepinephrine to 61.6, 62.0, and 56.9% of controls, respectively. Depletions of dopamine and norepinephrine could result in abnormal behavior of contaminated birds in the wild, and the detection of such depletions could become an important tool in assessing contaminant-induced behavioral aberrations in birds.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Dopamine and norepinephrine depletion in ring doves fed DDE, dieldrin, and Aroclor 1254
Series title:
Toxicology and Applied Pharmacology
DOI:
10.1016/0041-008X(80)90383-X
Volume
53
Issue:
1
Year Published:
1980
Language:
English
Contributing office(s):
Patuxent Wildlife Research Center
Description:
75-82
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Toxicology and Applied Pharmacology
First page:
75
Last page:
82
Number of Pages:
8