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Recovery of cholinesterase activity in mallard ducklings administered organophosphorus pesticides

Journal of Toxicology and Environmental Health

By:
,
DOI: 10.1080/15287398109530123

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Abstract

Oral doses of the organophosphorus pesticides acephate, dicrotophos, fensulfothion, fonofos, malathion, and parathion were administered to mallard ducklings (Anas platyrhynchos), and brain and plasma cholinesterase (ChE) activities were determined for up to 77 d after dosing. In vivo recovery of brain ChE activity to within 2 standard deviations of the mean activity of undosed birds occurred within 8 d, after being depressed an average of 25-58% at 24 h after dosing. In vivo recovery of plasma ChE appeared as fast as or faster than that of brain, but the pattern of recovery was more erratic and therefore statistical comparison with brain ChE recovery was not attempted. In vitro tests indicated that the potential for dephosphorylation to contribute to in vivo recovery of inhibited brain ChE differed among chemical treatments. Some ducklings died as a result of organophosphate dosing. In an experiment in which ducklings within each treatment group received the same dose (mg/kg), the brain ChE activity in birds that died was less than that in birds that survived. Brain ChE activities in ducklings that died were significantly different among pesticide treatments: fensulfothion > parathion> acephate > malathion (p < 0.05).

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Recovery of cholinesterase activity in mallard ducklings administered organophosphorus pesticides
Series title:
Journal of Toxicology and Environmental Health
DOI:
10.1080/15287398109530123
Volume
8
Issue:
5-6
Year Published:
1981
Language:
English
Publisher:
Taylor and Francis
Contributing office(s):
Patuxent Wildlife Research Center
Description:
885-897
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Journal of Toxicology and Environmental Health
First page:
885
Last page:
897
Number of Pages:
13