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Recovery of brain and plasma cholinesterase activities in ducklings exposed to organophosphorus pesticides

Archives of Environmental Contamination and Toxicology

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Abstract

Brain and plasma cholinesterase (ChE) activities were determined for mallard ducklings (Anas platyrhynchos) exposed to dicrotophos and fenthion. Recovery rates of brain ChE did not differ between ducklings administered a single oral dose vs. a 2-week dietary dose of these organophosphates. Exposure to the organophosphates, followed by recovery of brain ChE, did not significantly affect the degree of brain ChE inhibition or the recovery of ChE activity at a subsequent exposure. Recovery of brain ChE activity followed the general model Y = a + b(logX) with rapid recovery to about 50% of normal, followed by a slower rate of recovery until normal ChE activity levels were attained. Fenthion and dicrotophos-inhibited brain ChE were only slightly reactivated in vitro by pyridine-2-aldoxime methiodide, which suggested that spontaneous reactivation was not a primary method of recovery of ChE activity. Recovery of brain ChE activity can be modeled for interpretation of sublethal inhibition of brain ChE activities in wild birds following environmental applications of organophosphates. Plasma ChE activity is inferior to brain ChE activity for environmental monitoring, because of its rapid recovery and large degree of variation among individuals.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Recovery of brain and plasma cholinesterase activities in ducklings exposed to organophosphorus pesticides
Series title:
Archives of Environmental Contamination and Toxicology
Volume
10
Issue:
2
Year Published:
1981
Language:
English
Contributing office(s):
Patuxent Wildlife Research Center
Description:
215-229
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Archives of Environmental Contamination and Toxicology
First page:
215
Last page:
229
Number of Pages:
15