| Abstract: | Tissue and plasma concentrations and the biological half-life of tylosin in avian species of a variety of body sizes and metabolic rates were studied. The species chosen were eastern bobwhite quail (Colinus virginianus virginianus), pigeons (Columba livia), greater sandhill cranes (Grus canadensis tabida), and emus (Dromaius novaehollandiae). In the 1st phase of this study, tylosin was administered IM to quail, pigeons, and emus at a dosage rate of 25 mg/kg of body weight and to cranes at a dosage rate of 15 mg/kg. The average peak plasma concentrations of tylosin in quail, pigeons, cranes, and emus were 4.31, 5.63, 3.62, and 3.26 microgram/ml, respectively. These peak concentrations occurred at 0.5 to 1.5 hours after administration. The biological half-life of tylosin averaged 1.2 hours in quail, pigeons, and cranes, and was 4.7 hours in emus. In the 2nd phase of this study, tylosin concentrations in the tissues of quail, pigeons, and cranes were markedly higher than were plasma concentrations at corresponding sampling times. Six hours after antibiotic administration, tissue concentrations of tylosin in all species remained within the minimum inhibitory concentration for most pathogenic organisms. Dosage regimens of 25 mg of tylosin/kg 4 times daily for quail and pigeons, 15 mg/kg 3 times daily for cranes, and 25 mg/kg 3 times daily for emus would be needed to establish and maintain therapeutic tissue concentrations. |
| Genre: | Article |
| ProdID: | 5221768 |
| Citation Author: | Locke, D.; Bush, M.; Carpenter, J.W. |
| Citation Contributing Office: | Patuxent Wildlife Research Center |
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| Citation End Page: | 1810 |
| Citation Issue: | 10 |
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| Citation Language: | English |
| Citation Larger Work Title: | American Journal of Veterinary Research |
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| Citation Number Of Pages: | 4 |
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| Citation Phsyical Description: | 1807-1810 |
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| Citation Search Results Text: | Pharmacokinetics and tissue concentrations of tylosin in selected avian species; 1982; Article; Journal; American Journal of Veterinary Research; Locke, D.; Bush, M.; Carpenter, J.W. |
| Citation Start Page: | 1807 |
| Citation Volume: | 43 |
| Citation Year: | 1982 |
| Type: | citation/reference |
| Text: | Pharmacokinetics and tissue concentrations of tylosin in selected avian species; 1982; Article; Journal; American Journal of Veterinary Research; Locke, D.; Bush, M.; Carpenter, J.W. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| Date Other: | Wed, 16 Jun 2010 12:19 -0500 |
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