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Organophosphorus insecticide induced decrease in plasma luteinizing hormone concentration in white-footed mice

Toxicology Letters

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Abstract

Oral intubation of 50 and 100 mg/kg acephate inhibited brain acetylcholinesterase (AChE) activity by 45% and 56%, and reduced basal luteinizing hormone (LH) concentration by 29% and 25% after 4 h in white-footed mice (Peromyscus leucopus noveboracensis). Dietary exposure to 25, 100, and 400 ppm acephate for 5 days substantially inhibited brain AChE activity, but did not affect plasma LH concentration. These preliminary findings suggest that acute exposure to organophosphorus insecticides may affect LH secretion and possibly reproductive function.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Organophosphorus insecticide induced decrease in plasma luteinizing hormone concentration in white-footed mice
Series title:
Toxicology Letters
Volume
24
Issue:
1
Year Published:
1985
Language:
English
Contributing office(s):
Patuxent Wildlife Research Center
Description:
65-69
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Toxicology Letters
First page:
65
Last page:
69
Number of Pages:
5