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Divergent effects of postmortem ambient temperature on organophosphorus- and carbamate-inhibited brain cholinesterase activity in birds

Pesticide Biochemistry and Physiology

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DOI: 10.1016/0048-3575(89)90125-9

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Abstract

Time- and temperature-dependent postmortem changes in inhibited brain cholinesterase (ChE) activity may confound diagnosis of field poisoning of wildlife by anticholinesterase pesticide. Carbamate-inhibited ChE activity may return to normal within 1 to 2 days of exposure of intact carcass to moderate ambient temperature (18-32C). Organophosphorus-inhibited ChE activity becomes more depressed over the same time. Uninhibited ChE activity was resilient to above freezing temperature to 32C for 1 day and 25C for 3 days. Carbamate- and organophosphorus-inhibited ChE can be separated by incubation of homogenate for 1 hour at physiological temperatures; carbamylated ChE can be readily reactivated while phosphorylated ChE cannot.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Divergent effects of postmortem ambient temperature on organophosphorus- and carbamate-inhibited brain cholinesterase activity in birds
Series title:
Pesticide Biochemistry and Physiology
DOI:
10.1016/0048-3575(89)90125-9
Volume
33
Issue:
3
Year Published:
1989
Language:
English
Contributing office(s):
Patuxent Wildlife Research Center
Description:
264-275
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Pesticide Biochemistry and Physiology
First page:
264
Last page:
275
Number of Pages:
12