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Hepatic glutathione metabolism and lipid peroxidation in response to excess dietary selenomethionine and selenite in mallard ducklings

Journal of Toxicology and Environmental Health

By:
, , and
DOI: 10.1080/15287398909531296

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Abstract

Selenium from selenomethionine accumulated in a dose-dependent manner in the liver, resulting in a decrease in hepatic-reduced glutathione with a corresponding decrease in total hepatic thiols. There was a dose-dependent increase in the oxidized to reduced glutathione ratio, and an increase in lipid peroxidation. These findings indicate that Se in the diet at 10 ppm and higher causes significant sublethal alterations in mallard ducklings, and 20-40 ppm causes significant hepatotoxicity.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Hepatic glutathione metabolism and lipid peroxidation in response to excess dietary selenomethionine and selenite in mallard ducklings
Series title:
Journal of Toxicology and Environmental Health
DOI:
10.1080/15287398909531296
Volume
27
Issue:
2
Year Published:
1989
Language:
English
Publisher:
Taylor and Francis
Contributing office(s):
Patuxent Wildlife Research Center
Description:
263-271
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Journal of Toxicology and Environmental Health
First page:
263
Last page:
271