| Abstract: | This overview examines the utility of mixed-function oxygenase (MFO) enzymes as a bioeffects monitor for wildlife (amphibians, reptiles, birds and mammals) in view of their widespread use as indicators of contaminant exposure in aquatic invertebrates and fish. Phylogenetic trends in MFO activity, toxicological implications of induction and the relationship between contaminant exposure and MFO activity are discussed. Field studies using avian embryos and hatchlings suggest that MFO induction has utility for documenting contaminant exposure; however, findings in adult birds and mammals are equivocal. Age, sex and season are sources of variation that require consideration when undertaking field trials. Further understanding of MFO inducibility among species and application of recently developed analytical techniques including quantification of specific cytochrome P-450 isozymes are warranted. |
| Genre: | Article |
| ProdID: | 5222299 |
| Citation Author: | Rattner, B.A.; Hoffman, D.J.; Marn, C.M. |
| Citation Contributing Office: | Patuxent Wildlife Research Center |
| Citation Datum: | |
| Citation Day: | |
| Citation Edition: | |
| Citation Editor: | |
| Citation End Page: | 1102 |
| Citation Issue: | 12 |
| Citation Keywords: | |
| Citation Language: | English |
| Citation Larger Work Title: | Environmental Toxicology and Chemistry |
| Citation LatN: | |
| Citation LatS: | |
| Citation LonE: | |
| Citation LonW: | |
| Citation Month: | |
| Citation No Pagination: | |
| Citation Number Of Pages: | 10 |
| Citation Online Only Flag: | |
| Citation Phsyical Description: | 1093-1102 |
| Citation Projection: | |
| Citation Public Comments: | |
| Citation Publisher: | |
| Citation Series: | |
| Citation Series Code: | |
| Citation Series Number: | |
| Citation Search Results Text: | Use of mixed-function oxygenases to monitor contaminant exposure in wildlife; 1989; Article; Journal; Environmental Toxicology and Chemistry; Rattner, B.A.; Hoffman, D.J.; Marn, C.M. |
| Citation Start Page: | 1093 |
| Citation Volume: | 8 |
| Citation Year: | 1989 |
| Type: | citation/reference |
| Text: | Use of mixed-function oxygenases to monitor contaminant exposure in wildlife; 1989; Article; Journal; Environmental Toxicology and Chemistry; Rattner, B.A.; Hoffman, D.J.; Marn, C.M. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| URL (DOCUMENT): | http://www3.interscience.wiley.com/journal/122657098/abstract |
| Date Other: | Wed, 16 Jun 2010 12:19 -0500 |
| Publisher: | |
