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A resource conservative procedure for comparison of dose-response relationships

Environmental Toxicology and Chemistry

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Abstract

The evaluation of effects of toxicants on a wildlife community can be complicated by varying responses among the community's constituent populations. Even within populations, considerable variability in dose-response relations may result from different avenues of exposure to the toxicant. Full scale investigations of the dose-response relations among a variety of species and avenues of exposure can therefore be prohibitively expensive, whether this expense is measured by the number of experimental animals needed, by the human resources committed to the study, or by laboratory expenses. We propose an abbreviated protocol for investigations of multiple dose-response relations that is designed to limit these expenses. The protocol begins with the judicious choice of a baseline dose-response relation to be estimated by a full scale study involving a minimum of 5 doses levels, with 10 subjects per dose level. This relation is then used as the basis for rapid screening of subsequent dose-response relations, which are compared to the baseline relation by testing for differences in the median effective dosages. These secondary studies can consist of as few as 14 animals exposed to the estimated LC50 from the baseline study. We describe MS-DOS compatible software available from the authors which can be used to analyze these data.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
A resource conservative procedure for comparison of dose-response relationships
Series title:
Environmental Toxicology and Chemistry
Volume
15
Issue:
9
Year Published:
1996
Language:
English
Contributing office(s):
Patuxent Wildlife Research Center
Description:
1612-1617
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Environmental Toxicology and Chemistry
First page:
1612
Last page:
1617
Number of Pages:
6