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Regional cholinesterase activity in white-throated sparrow brain is differentially affected by acephate (Orthene?)

Comparative Biochemistry and Physiology, C

By:
, , , , and
DOI: 10.1016/0742-8413(95)02109-4

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Abstract

Effects of a 14-day dietary exposure to an organophosphorus pesticide, acephate (acetylphosphoramidothioic acid O,S-dimethyl ester), were determined on cholinesterase activity in three regions (basal ganglia, hippocampus, and hypothalamus) of the white-throated sparrow, Zonotrichia albicollis, brain. All three regions experienced depressed cholinesterase activity between 0.5-2 ppm acephate. The regions exhibited cholinesterase recovery at 2-16 ppm acephate; however, cholinesterase activity dropped and showed no recovery at higher dietary levels (>16 ppm acephate). Evidence indicates that the recovery is initiated by the magnitude of depression, not the duration. In general, as acephate concentration increased, differences in ChE activity among brain regions decreased. Three terms are introduced to describe ChE response to acephate exposure: (1) ChE resistance threshold, (2) ChE compensation threshold, and (3) ChE depression threshold. It is hypothesized that adverse effects to birds in the field may occur at pesticide exposure levels customarily considered negligible.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Regional cholinesterase activity in white-throated sparrow brain is differentially affected by acephate (Orthene?)
Series title:
Comparative Biochemistry and Physiology, C
DOI:
10.1016/0742-8413(95)02109-4
Volume
113
Issue:
3
Year Published:
1996
Language:
English
Contributing office(s):
Patuxent Wildlife Research Center
Description:
381-386
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Comparative Biochemistry and Physiology, C
First page:
381
Last page:
386