thumbnail

Developmental toxicity of PCB 126 (3,3',4,4',5-pentachlorobiphenyl) in nestling American kestrels (Falco sparverius)

Fundamental and Applied Toxicology

4945_Hoffman.pdf
By:
, , , , , , ,

Links

Abstract

Planar PCB congeners are embryotoxic and teratogenic to birds including American kestrels. The developmental toxicity of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) was studied in the post-hatching kestrel as a model for the eagle. Nestlings were orally dosed for 10 days with 5 ul/g body weight of corn oil (controls) or the planar PCB 126 at concentrations of 50, 250, or 1000 ng/g body weight. Dosing with 50 ng/g of PCB 126 resulted in a hepatic concentration of 156 ng/g w.w., liver enlargement and mild coagulative necrosis, and over ten-fold increases in hepatic microsomal ethoxyresorufin-O-dealkylase (EROD) and benzyloxyresorufin-O-dealkylase (BROD), and approximately a 5-fold increase in methoxyresorufin-O-dealkylase (MROD). At this dose, mild to moderate lymphoid depletion of the spleen was apparent, and decreased follicle size and content of the thyroid. At 250 ng/g, concentration of PCB 126 in the liver was 380 ng/g with increasing multifocal coagulative necrosis, decreased bone growth, decreased spleen weight with lymphocyte depletion of the spleen and bursa, and degenerative lesions of the thyroid. At 1000 ng/g, the liver concentration was 1098 ng/g, accompanied by decreased bursa weight, decreased hepatic thiol concentration and increased plasma enzyme activities (ALT, AST, and LDH-L) in addition to the previous effects. Highly significant positive correlations were noted between liver concentrations of PCB 126 and the ratio of oxidized to reduced glutathone. These findings indicate that nestling kestrels are more susceptible to PCB 126 toxicity than adults, but less sensitive than embryos, and that planar PCBs are of potential hazard to nestling birds.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Developmental toxicity of PCB 126 (3,3',4,4',5-pentachlorobiphenyl) in nestling American kestrels (Falco sparverius)
Series title:
Fundamental and Applied Toxicology
Volume
34
Issue:
2
Year Published:
1996
Language:
English
Contributing office(s):
Patuxent Wildlife Research Center
Description:
188-200
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Fundamental and Applied Toxicology
First page:
188
Last page:
200
Number of Pages:
13