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Effects of 3,3',4,4',5-pentachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin injected into the yolks of double-crested cormorant (Phalacrocorax auritus) eggs prior to incubation

Environmental Toxicology and Chemistry

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Abstract

Double-crested cormorant (Phalacrocorax auritus) eggs were injected with either 3,3',4,4',5-pentachlorobiphenyl (polychlorinated biphenyl [PCB] 126; 70-698 ?g/kg egg) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 1.3-11.7 ?g/kg egg) prior to incubation. These compounds were injected into the yolks of cormorant eggs collected from incomplete clutches at isolated colonies on Lake Winnipegosis, Manitoba, Canada. Eggs were incubated for approximately 26 to 28 d. After hatching the brain, bursa, heart, liver, and spleen were dissected and weighed. Torsos were preserved in formalin for examination of the gonads. Median lethal doses (LD50s) calculated from mortality data at hatching were 177 and 4.0 ?g/kg egg for PCB 126 and TCDD, respectively. No significant differences were found in the incidence of developmental abnormalities in any of the treatment groups. Bursa weights were significantly less in the greatest (11.7 ?g/kg egg) TCDD group compared to the vehicle control group. Spleen weights were significantly less in the 349 ?g PCB 126/kg egg and the 5.4 and 11.7 ?g TCDD/kg egg groups when compared to the vehicle control group. No histological alterations of the gonads were found. Hepatic ethoxyresorufin-O-deethylase activity in all PCB 126 and TCDD dose groups was significantly greater compared to the control activity. The toxic equivalency factor for PCB 126 was 0.02

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Effects of 3,3',4,4',5-pentachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin injected into the yolks of double-crested cormorant (Phalacrocorax auritus) eggs prior to incubation
Series title:
Environmental Toxicology and Chemistry
Volume
17
Issue:
10
Year Published:
1998
Language:
English
Contributing office(s):
Patuxent Wildlife Research Center
Description:
2035-2040
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
First page:
2035
Last page:
2040
Number of Pages:
6