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Cytochrome P450 responses and PCB congeners in pipping heron embryos from Virginia, the Great Lakes and San Francisco Bay

Society of Environmental Toxicology and Chemistry, annual meeting abstract book

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Abstract

Pipping black-crowned night-heron (Nvcticorax nvcticorax) embryos were collected from undisturbed (Chincoteague National Wildlife Refuge VA; CNWR) and industrialized (Cat Island, Green Bay WI and San Francisco Bay, CA; SFB) locations. Hepatic monooxygenases (AHH, EROD, BROD, ECOD) were induced up to 100-fold, and were correlated (r=0.50 to 0.72) with total PCB burdens (N =61 embryos). A subset of 30 embryos have now been analyzed by GC/MS for 12 AHH-active PCB congeners and by Western blot for cytochromes P450lA and P450llB. At Cat Island, concentrations of 8 congeners were greater (P <0.05) than at CNWR. P450lA and P450llB were detected in 44% and 100% of the Cat Island embryos compared to 8% and 33% of the CNWR + SFB embryos. Cytochrome P450 parameters were correlated with the total PCBs (r =0.44 to 0.67) and with at least 9 PCB congeners (r =0.39 to 0.77). Since P450 responses might be affected by other contaminants, sample extract potency in the H411E rat hepatoma bioassay is being determined to study relationships among dioxin equivalents and cytochrome P450 parameters.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Cytochrome P450 responses and PCB congeners in pipping heron embryos from Virginia, the Great Lakes and San Francisco Bay
Series title:
Society of Environmental Toxicology and Chemistry, annual meeting abstract book
Volume
13
Year Published:
1992
Language:
English
Contributing office(s):
Patuxent Wildlife Research Center
Description:
133 (abstract no. 580)
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Society of Environmental Toxicology and Chemistry, annual meeting abstract book
First page:
133 (abstr