Mammalian sensitivity to elemental gold (Au?)
Biological Trace Element Research
6164_Eisler.pdf
By: R. Eisler
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Abstract
There is increasing documentation of allergic contact dermatitis and other effects from gold jewelry, gold dental restorations, and gold implants. These effects were especially pronounced among females wearing body-piercing gold objects. One estimate of the prevalence of gold allergy worldwide is 13%, as judged by patch tests with monovalent organogold salts. Eczema of the head and neck was the most common response of individuals hypersensitive to gold, and sensitivity can last for at least several years. Ingestion of beverages containing flake gold can result in allergic-type reactions similar to those seen in gold-allergic individuals exposed to gold through dermal contact and other routes. Studies with small laboratory mammals and injected doses of colloidal gold showed increased body temperatures, accumulations in reticular cells, and dose enhancement in tumor therapy; gold implants were associated with tissue injuries. It is proposed that Au? toxicity to mammals is associated, in part, with formation of the more reactive Au+ and Au3+ species.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Mammalian sensitivity to elemental gold (Au?) |
| Series title | Biological Trace Element Research |
| DOI | 10.1385/BTER:100:1:001 |
| Volume | 100 |
| Issue | 1 |
| Year Published | 2004 |
| Language | English |
| Publisher | U.S. Fish and Wildlife Service |
| Contributing office(s) | Patuxent Wildlife Research Center |
| Description | 1-18 |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Biological Trace Element Research |
| First page | 1 |
| Last page | 18 |
| Google Analytic Metrics | Metrics page |