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Hepatic microsomal N-oxidation and N-demethylation of N,N-dimethylaniline in red-winged blackbird compared with rat and other birds

Life Sciences

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Abstract

Hepatic microsomes prepared from red-winged blackbirds and albino rats were incubated with N,N-dimethylaniline (DMA)_in complete incubation mixtures at pH 7.9 and 37?C for 10 min. Formaldehyde and N,N-dimethylaniline--oxide produced from DMA were measured. Redwings were found to have significantly lower N-demethylation activities than rats, and redwings had only marginal or no N-oxidation activities. Hepatic microsomes from redwings did not further metabolize the N-oxide. The N-oxidation and N-demethylation activities of brown-headed cowbirds, common grackles, and starlings were similar to those of redwings.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Hepatic microsomal N-oxidation and N-demethylation of N,N-dimethylaniline in red-winged blackbird compared with rat and other birds
Series title:
Life Sciences
Volume
17
Issue:
5
Year Published:
1975
Language:
English
Contributing office(s):
Patuxent Wildlife Research Center
Description:
819-825
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
First page:
819
Last page:
825
Number of Pages:
7