Hepatic microsomal N-oxidation and N-demethylation of N,N-dimethylaniline in red-winged blackbird compared with rat and other birds

Pan, H.P.; Fouts, J.R.; Devereux, T.R.

Abstract:

Hepatic microsomes prepared from red-winged blackbirds and albino rats were incubated with N,N-dimethylaniline (DMA)_in complete incubation mixtures at pH 7.9 and 37?C for 10 min. Formaldehyde and N,N-dimethylaniline--oxide produced from DMA were measured. Redwings were found to have significantly lower N-demethylation activities than rats, and redwings had only marginal or no N-oxidation activities. Hepatic microsomes from redwings did not further metabolize the N-oxide. The N-oxidation and N-demethylation activities of brown-headed cowbirds, common grackles, and starlings were similar to those of redwings.

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Article

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5224598

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Pan, H.P.; Fouts, J.R.; Devereux, T.R.

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Patuxent Wildlife Research Center

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825

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English

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Life Sciences

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819-825

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Hepatic microsomal N-oxidation and N-demethylation of N,N-dimethylaniline in red-winged blackbird compared with rat and other birds; 1975; Article; Journal; Life Sciences; Pan, H.P.; Fouts, J.R.; Devereux, T.R.