thumbnail

Percutaneous absorption of several chemicals, some pesticides included, in the red-winged blackbird

Environmental Physiology and Biochemistry

7119_Rogers.pdf
By:
, , and

Links

  • The Publications Warehouse does not have links to digital versions of this publication at this time
  • Download citation as: RIS

Abstract

Percutaneous absorption in vivo through the skin of the feet of the red-winged blackbird (Agelaius phoeniceus) has been investigated. Absorption after 18-24 hours exposure to 0.01 M solutions of salicylic acid, caffeine, urea, 2,4-D, dieldrin, diethylstilbesterol, and DDT was measured. Of these, only DDT and diethylstilbesterol were not absorbed to a measurable degree. The solvents ethanol, dimethylsulfoxide (DMSO), and vegetable oil were compared with water in their effects on the absorption ofcaffeine, urea, and salicylic acid. Ethanol, DMSO,and oil each decreased percutaneous absorption of salicylic acid. DMSO increased absorption of caffeine, and ethanol had no effect on it. Neither DMSO nor ethanol affected penetration of urea. Partition coefficients (K) (epidermis/water) were determined for all seven penetrants. Compounds with higher values of K showed lower percutaneous absorption. These findings suggest that K may be useful to predict percutaneous absorption in vivo. It appears unlikely that percutaneous absorption contributes greatly to the body burden of 2,4-D and dieldrin in A. phoeniceus.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Percutaneous absorption of several chemicals, some pesticides included, in the red-winged blackbird
Series title:
Environmental Physiology and Biochemistry
Volume
4
Issue:
3
Year Published:
1974
Language:
English
Contributing office(s):
Patuxent Wildlife Research Center
Description:
104-111
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Environmental Physiology and Biochemistry
First page:
104
Last page:
111