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Protective efficacy of a recombinant subunit West Nile virus vaccine in domestic geese (Anser anser)

Vaccine

By:
, , , , ,
DOI: 10.1016/j.vaccine.2008.08.011

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Abstract

Introduction of the West Nile virus (WNV) to Hawai'i will undoubtedly devastate many populations of critically endangered avian species indigenous to Hawai'i. The protective efficacy of a protein-based WNV subunit vaccine formulated with adjuvant was evaluated in domestic geese as a surrogate species for the endangered Ne??ne??, the state bird of Hawai'i. Prevention of viremia following viral infection of vaccinated birds was used as the clinical endpoint of protection. ELISA and plaque reduction neutralization tests demonstrate that significant levels of vaccine antigen-specific antibody were produced in groups of birds vaccinated with 5 or 10 ??g of the WN-80E antigen formulated with ISA720 adjuvant. Moreover, after challenge with WNV, no viremia was detected in vaccinated birds, whereas viremia was detected up to 4 days after and virus was detected by oral swab for 6 days after infection among control groups. Safe and effective vaccination of managed or captive endangered bird populations will protect species with critically low numbers that could not survive the added mortality of introduced disease. ?? 2008 Elsevier Ltd.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Protective efficacy of a recombinant subunit West Nile virus vaccine in domestic geese (Anser anser)
Series title:
Vaccine
DOI:
10.1016/j.vaccine.2008.08.011
Volume
26
Issue:
42
Year Published:
2008
Language:
English
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Vaccine
First page:
5338
Last page:
5344