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Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia, Daphnia magna, in a continuous exposure test system

Bulletin of Environmental Contamination and Toxicology

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Abstract

Diphenhydramine hydrochloride (DH; Benadryl TM, an over-the-counter antihistamine) and erythromycin thiocyanate (ET; a commonly used macrolide antibiotic) are pharmaceutical compounds whose chronic toxicity to Daphnia magna had not been characterized. Continuous exposure to DH concentrations about 5 times greater than the maximum reported environmental concentration of 0.023 lg/L for 21 days or to ET concentrations about 40 times the maximum reported environmental concentration of 6 (mu or u)g/L for 21 days did not significantly impact D. magna survival and production. In this study the no observable effect concentration for DH was 0.12 (mu or u)g/L and for ET was 248 (mu or u)g/L.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia, Daphnia magna, in a continuous exposure test system
Series title:
Bulletin of Environmental Contamination and Toxicology
Volume
85
Issue:
5
Year Published:
2010
Language:
English
Publisher:
Springer
Publisher location:
Netherlands
Contributing office(s):
Upper Midwest Environmental Sciences Center
Description:
5 p.
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Bulletin of Environmental Contamination and Toxicology
First page:
447
Last page:
451
Country:
United States