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Comparative toxicity of diphacinone to northern bobwhite (Colinus virginianus) and American kestrels (Falco sparverius)

Proceedings of the 24th Vertebrate Pest Conference

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Abstract

The acute oral toxicity of the anticoagulant rodenticide diphacinone was found to be about 20 times greater to American kestrels (LD50=97 mg/kg) than to northern bobwhite (LD50=2,014 mg/kg). Several precise and sensitive clotting assays (prothrombin time, Russell's Viper venom time, thrombin clotting time) were adapted for use in these species, and this combination of assays is recommended to detect effects of diphacinone and other rodenticides on coagulation. Oral administration of diphacinone over a range of doses (sublethal to the extrapolated LD15) prolonged prothrombin time and Russell's Viper venom time within 24 to 48 hrs post-exposure. Prolongation of in vitro clotting time reflects impaired coagulation complex activity and was detected before or at the onset of overt signs of toxicity and lethality. These data will assist in the development of a pharmacodynamic model to assess and predict rodenticide toxicity to non-target avian species.

Additional Publication Details

Publication type:
Book
Publication Subtype:
Conference publication
Title:
Comparative toxicity of diphacinone to northern bobwhite (Colinus virginianus) and American kestrels (Falco sparverius)
Series title:
Proceedings of the 24th Vertebrate Pest Conference
Volume
24
Year Published:
2010
Language:
English
Publisher:
University of California-Davis
Publisher location:
Davis, CA
Contributing office(s):
Patuxent Wildlife Research Center
Description:
7 p.
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Number of Pages:
7
Conference Title:
Vertebrate Pest Conference
Conference Location:
Sacramento, CA
Conference Date:
22-FEB-10
Country:
United States