High-performance liquid chromatographic resolution and quantification of a dilacton antibiotic mixture (antimycin A)
Journal of Chromatography
By: S. L. Abidi
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Abstract
High-performance liquid chromatographic (HPLC) conditions are presented for the separation and quantitative determination of a homologous antibiotic complex (antimycin A). Combined HPLC and chemical ionization mass spectrometry proved to be exceptionally useful for the structural identification of chromatographic components. Using electrochemical, fluorescence, and ultraviolet detectors, the minimum detectable amounts of the antibiotics were found to be in the ranges 0.10–1.12, 0.31–1.69, and 4.10–28.2 ng, respectively. Advantages of the preparation of Dns derivatives for use in fluorescence detection are discussed. Application of the HPLC technique to the analysis of the antibiotic mixture in organic tissues is demonstrated.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | High-performance liquid chromatographic resolution and quantification of a dilacton antibiotic mixture (antimycin A) |
| Series title | Journal of Chromatography |
| DOI | 10.1016/s0021-9673(00)81792-6 |
| Volume | 234 |
| Year Published | 1982 |
| Language | English |
| Publisher | Elsevier |
| Contributing office(s) | Upper Midwest Environmental Sciences Center |
| Description | 14 p. |
| First page | 187 |
| Last page | 200 |
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