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A review of methods to estimate cause-specific mortality in presence of competing risks

Journal of Wildlife Management

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By:
and
DOI: 10.2193/0022-541X(2006)70[1544:AROMTE]2.0.CO;2

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Abstract

Estimating cause-specific mortality is often of central importance for understanding the dynamics of wildlife populations. Despite such importance, methodology for estimating and analyzing cause-specific mortality has received little attention in wildlife ecology during the past 20 years. The issue of analyzing cause-specific, mutually exclusive events in time is not unique to wildlife. In fact, this general problem has received substantial attention in human biomedical applications within the context of biostatistical survival analysis. Here, we consider cause-specific mortality from a modern biostatistical perspective. This requires carefully defining what we mean by cause-specific mortality and then providing an appropriate hazard-based representation as a competing risks problem. This leads to the general solution of cause-specific mortality as the cumulative incidence function (CIF). We describe the appropriate generalization of the fully nonparametric staggered-entry Kaplan–Meier survival estimator to cause-specific mortality via the nonparametric CIF estimator (NPCIFE), which in many situations offers an attractive alternative to the Heisey–Fuller estimator. An advantage of the NPCIFE is that it lends itself readily to risk factors analysis with standard software for Cox proportional hazards model. The competing risks–based approach also clarifies issues regarding another intuitive but erroneous "cause-specific mortality" estimator based on the Kaplan–Meier survival estimator and commonly seen in the life sciences literature.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
A review of methods to estimate cause-specific mortality in presence of competing risks
Series title:
Journal of Wildlife Management
DOI:
10.2193/0022-541X(2006)70[1544:AROMTE]2.0.CO;2
Volume
70
Issue:
6
Year Published:
2006
Language:
English
Publisher:
The Wildlife Society
Publisher location:
Bethesda, MD
Contributing office(s):
National Wildlife Health Center
Description:
12 p.
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Journal of Wildlife Management
First page:
1544
Last page:
1555
Number of Pages:
12