| Abstract: | Clostridium botulinum neurotoxins inhibit acetylcholine release at neuromuscular junctions. Agents stimulating neurotransmitter efflux, such as 3,4-diaminopyridine (3,4-DAP), could be useful for botulism therapy. Treatment with 3,4-DAP (8 mg/kg hourly, beginning 3 hr after toxin injection) failed to increase the survival times of mice receiving 10, 20 or 40 LD50 type C, but did prolong the survival of those receiving 20 LD50 type A. This difference in 3,4-DAP efficacy may reflect variations in the molecular mechanism of action of types A and C botulinum neurotoxins. |
| Genre: | Article |
| ProdID: | 70006635 |
| Citation Author: | Siegel, L. S.; Price, J. I. |
| Citation Contributing Office: | National Wildlife Health Center |
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| Citation End Page: | 1018 |
| Citation Issue: | 9 |
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| Citation Language: | English |
| Citation Larger Work Title: | Toxicon |
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| Citation Number Of Pages: | 4 |
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| Citation Phsyical Description: | 4 p. |
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| Citation Public Comments: | Abstract has subscript/superscript to be fixed |
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| Citation Search Results Text: | Ineffectiveness of 3,4-diaminopyridine as a therapy for type C botulism.; 1987; Article; Journal; Toxicon; Siegel, L. S.; Price, J. I. |
| Citation Start Page: | 1015 |
| Citation Volume: | 25 |
| Citation Year: | 1987 |
| Type: | citation/reference |
| Text: | Ineffectiveness of 3,4-diaminopyridine as a therapy for type C botulism.; 1987; Article; Journal; Toxicon; Siegel, L. S.; Price, J. I. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| URL (DIGITAL OBJECT IDENTIFIER): | http://dx.doi.org/10.1016/0041-0101(87)90166-8 |
| Date Other: | Sun, 1 Jan 2012 18:59 -0600 |
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