thumbnail

Ineffectiveness of 3,4-diaminopyridine as a therapy for type C botulism.

Toxicon

Abstract has subscript/superscript to be fixed
By:
,
DOI: 10.1016/0041-0101(87)90166-8

Links

Abstract

Clostridium botulinum neurotoxins inhibit acetylcholine release at neuromuscular junctions. Agents stimulating neurotransmitter efflux, such as 3,4-diaminopyridine (3,4-DAP), could be useful for botulism therapy. Treatment with 3,4-DAP (8 mg/kg hourly, beginning 3 hr after toxin injection) failed to increase the survival times of mice receiving 10, 20 or 40 LD50 type C, but did prolong the survival of those receiving 20 LD50 type A. This difference in 3,4-DAP efficacy may reflect variations in the molecular mechanism of action of types A and C botulinum neurotoxins.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Ineffectiveness of 3,4-diaminopyridine as a therapy for type C botulism.
Series title:
Toxicon
DOI:
10.1016/0041-0101(87)90166-8
Volume
25
Issue:
9
Year Published:
1987
Language:
English
Contributing office(s):
National Wildlife Health Center
Description:
4 p.
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
First page:
1015
Last page:
1018
Number of Pages:
4