Methods of preparation of carbon-14 and deuterium labeled N-nitroso-2(3,7-dimethyl-2,6-octadienyl) aminoethanols are described. The primary synthetic method involved alkylation of ethanolamine or ethylglycine with suitable chlorides and subsequent mild nitrosation. Isomeric 14C-nitrosamines were also prepared by selective -cleavage of the di-substituted ethanolamine with nitrous acid.
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Synthesis of carbon-14 and deuterium labeled N-nitroso-2 (3',7'-dimethyl-2',6'-octadienyl) aminoethanols
Journal of Labelled compounds and Radiopharmaceuticals