| Abstract: | Aquaflor, a feed premix containing the broad spectrum antibacterial agent florfenicol (50% w/w), is being developed for use to control enteric septicemia (ESC) in channel catfish Ictalurus punctatus caused by the gram-negative enterobacterium Edwardsiella ictaluri. The recommended dose of Aquaflor to control ESC is 10 mg/kg body weight (BW)/day for 10 days. The study objective was to determine the safety of Aquaflor administered in feed to channel catfish at doses of 0 (control), 10, 30, and 50 mg/kg BW/day for 20 consecutive days. Parameters evaluated included daily mortality, behavioral (appetite, distribution, flight/fright response), and water chemistry observations, initial and terminal weight measurements, and gross and microscopic pathology. Medicated feed consumption was 67-86% of target with group mean doses of 8.5 mg/kg BW/day, 24.6 mg/kg BW/day, and 34.9 mg/kg BW/day. There were no mortalities or clinically observable changes noted at any of the dose levels tested. Aquaflor-related changes were limited to the food consumption and histopathology data. Although Aquaflor-related decreased feed consumption was noted in the 30 and 50 mg/kg BW/day groups, there were no differences in fish growth among the treatment groups. Aquaflor-related histopathology findings were limited to a histomorphologically evident dose-dependent decrease in hematopoietic/lymphopoietic tissue in the anterior kidneys, posterior kidneys, and spleens of channel catfish. |
| Genre: | Article |
| ProdID: | 70006850 |
| Citation Author: | Gaikowski, Mark P.; Wolf, Jeffery C.; Endris, Richard G.; Gingerich, William H. |
| Citation Contributing Office: | Upper Midwest Environmental Sciences Center |
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| Citation End Page: | 697 |
| Citation Issue: | 6 |
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| Citation Language: | English |
| Citation Larger Work Title: | Toxicologic Pathology |
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| Citation Number Of Pages: | 9 |
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| Citation Phsyical Description: | 9 p. |
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| Citation Public Comments: | None |
| Citation Publisher: | SAGE Publications |
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| Citation Search Results Text: | Safety of aquaflor (florfenicol, 50% type a medicated article), administered in feed to channel catfish, Ictalurus punctatus; 2003; Article; Journal; Toxicologic Pathology; Gaikowski, Mark P.; Wolf, Jeffery C.; Endris, Richard G.; Gingerich, William H. |
| Citation Start Page: | 689 |
| Citation Volume: | 31 |
| Citation Year: | 2003 |
| Type: | citation/reference |
| Text: | Safety of aquaflor (florfenicol, 50% type a medicated article), administered in feed to channel catfish, Ictalurus punctatus; 2003; Article; Journal; Toxicologic Pathology; Gaikowski, Mark P.; Wolf, Jeffery C.; Endris, Richard G.; Gingerich, William H. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| URL (DIGITAL OBJECT IDENTIFIER): | http://dx.doi.org/10.1080/01926230390241828 |
| Date Other: | Wed, 1 Jan 2003 10:10 -0600 |
| Publisher: | SAGE Publications |
