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Herpetic keratoconjunctivitis: Therapy with synthetic double-stranded RNA

Science

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, , , , , , and

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Abstract

A study was undertaken in rabbits to determine how late in the course of keratoconjunctivitis caused by herpes simplex recovery could be effected by an inducer of interferon. Interferon was induced by means of synthetic double-stranded RNA copolymer formed with polynosinic acid : polycytidilic acid RNA. Therapy promotes recovery from severe and fully established keratoconjunctivitis for which treatment was begun as late as 3 days after virus inoculation. No drug toxicity was observed in the therapeutic dose range. These findings further support the proposed role of the interferon mechanism in the natural recovery of already established viral infection. They also suggest the usefulness of interferon inducers in viral infections of man.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Herpetic keratoconjunctivitis: Therapy with synthetic double-stranded RNA
Series title:
Science
Volume
162
Issue:
3855
Year Published:
1968
Language:
English
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Science
First page:
811
Last page:
813