| Abstract: | A study was undertaken in rabbits to determine how late in the course of keratoconjunctivitis caused by herpes simplex recovery could be effected by an inducer of interferon. Interferon was induced by means of synthetic double-stranded RNA copolymer formed with polynosinic acid : polycytidilic acid RNA. Therapy promotes recovery from severe and fully established keratoconjunctivitis for which treatment was begun as late as 3 days after virus inoculation. No drug toxicity was observed in the therapeutic dose range. These findings further support the proposed role of the interferon mechanism in the natural recovery of already established viral infection. They also suggest the usefulness of interferon inducers in viral infections of man. |
| Genre: | Article |
| ProdID: | 70011593 |
| Citation Author: | Friedman, I.; Evans, C.; Meighan, C. W.; Foote, L. J.; Aiello, P. V.; Park, J. H.; Baron, S. |
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| Citation End Page: | 813 |
| Citation Issue: | 3855 |
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| Citation Language: | English |
| Citation Larger Work Title: | Science |
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| Citation Number Of Pages: | 3 |
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| Citation Search Results Text: | Herpetic keratoconjunctivitis: Therapy with synthetic double-stranded RNA; 1968; Article; Journal; Science; Friedman, I.; Evans, C.; Meighan, C. W.; Foote, L. J.; Aiello, P. V.; Park, J. H.; Baron, S. |
| Citation Start Page: | 811 |
| Citation Volume: | 162 |
| Citation Year: | 1968 |
| Type: | citation/reference |
| Text: | Herpetic keratoconjunctivitis: Therapy with synthetic double-stranded RNA; 1968; Article; Journal; Science; Friedman, I.; Evans, C.; Meighan, C. W.; Foote, L. J.; Aiello, P. V.; Park, J. H.; Baron, S. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| Date Other: | Mon, 1 Jan 1968 00:00 -0600 |
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