| Abstract: | A two compartment pharmacokinetic model was developed which describes the uptake and elimination of 5,5‘,6-trichlorobiphenyl (TCB) and pentachlorophenol (PCP) in the midge, Chironomus riparius. C. riparius were exposed to nominal TCB (2 ??g L-1) and PCP (9 ??g L-1) concentrations during a 16 h static uptake phase. Depuration was determined over approximately 45 h using a flowthrough system without feeding. The uptake clearance (P) was 330 ?? 61 ml g-1 midge h-1 for TCB and 55 ?? 4 ml g-1 midge h-1 for PCP, while measured bioconcentration factors (BCF) were 35,900 and 458 for TCB and PCP, respectively. Overall, the clearance-volume- based pharmacokinetic model predicted BCF values that were consistent with published values as well as with BCF values obtained from the octanol-water partition coefficient (K(ow)). |
| Genre: | Article |
| ProdID: | 70018015 |
| Citation Author: | Lydy, M. J.; Hayton, W. L.; Staubus, A. E.; Fisher, S. W. |
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| Citation End Page: | 256 |
| Citation Issue: | 2 |
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| Citation Language: | English |
| Citation Larger Work Title: | Archives of Environmental Contamination and Toxicology |
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| Citation Number Of Pages: | 6 |
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| Citation Search Results Text: | Bioconcentration of 5,5‘,6-trichlorobiphenyl and pentachlorophenol in the midge, Chironomus riparius, as measured by a pharmacokinetic model; 1994; Article; Journal; Archives of Environmental Contamination and Toxicology; Lydy, M. J.; Hayton, W. L.; Staubus, A. E.; Fisher, S. W. |
| Citation Start Page: | 251 |
| Citation Volume: | 26 |
| Citation Year: | 1994 |
| Type: | citation/reference |
| Text: | Bioconcentration of 5,5‘,6-trichlorobiphenyl and pentachlorophenol in the midge, Chironomus riparius, as measured by a pharmacokinetic model; 1994; Article; Journal; Archives of Environmental Contamination and Toxicology; Lydy, M. J.; Hayton, W. L.; Staubus, A. E.; Fisher, S. W. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| Date Other: | Sat, 1 Jan 1994 00:00 -0600 |
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