Application of mixed-mode, solid-phase extraction in environmental and clinical chemistry. Combining hydrogen-bonding, cation-exchange and Van der Waals interactions
Journal of Chromatography A
By: M. S. Mills, E. M. Thurman, and M.J. Pedersen
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Abstract
Silica- and styrene-divinylbenzene-based mixed-mode resins that contain C8, C18 and sulphonated cation-exchange groups were compared for their efficiency in isolation of neutral triazine compounds from water and of the basic drug, benzoylecgonine, from urine. The triazine compounds were isolated by a combination of Van der Waals and hydrogen-bonding interactions, and benzoylecgonine was isolated by Van der Waals interactions and cation exchange. All analytes were eluted with a polar organic solvent contaning 2% ammonium hydroxide. Larger recoveries (95%) were achieved on copolymerized mixed-mode resins where C18 and sulfonic acid are in closer proximity than on 'blended' mixed-mode resins (60-70% recovery).
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Application of mixed-mode, solid-phase extraction in environmental and clinical chemistry. Combining hydrogen-bonding, cation-exchange and Van der Waals interactions |
| Series title | Journal of Chromatography A |
| DOI | 10.1016/0021-9673(93)80349-D |
| Volume | 629 |
| Issue | 1 |
| Year Published | 1993 |
| Language | English |
| Publisher | Elsevier |
| Contributing office(s) | Toxic Substances Hydrology Program |
| Description | 11 p. |
| First page | 11 |
| Last page | 21 |
| Google Analytic Metrics | Metrics page |