thumbnail

Application of mixed-mode, solid-phase extraction in environmental and clinical chemistry. Combining hydrogen-bonding, cation-exchange and Van der Waals interactions

By:
, ,
DOI: 10.1016/0021-9673(93)80349-D

Links

Abstract

Silica- and styrene-divinylbenzene-based mixed-mode resins that contain C8, C18 and sulphonated cation-exchange groups were compared for their efficiency in isolation of neutral triazine compounds from water and of the basic drug, benzoylecgonine, from urine. The triazine compounds were isolated by a combination of Van der Waals and hydrogen-bonding interactions, and benzoylecgonine was isolated by Van der Waals interactions and cation exchange. All analytes were eluted with a polar organic solvent contaning 2% ammonium hydroxide. Larger recoveries (95%) were achieved on copolymerized mixed-mode resins where C18 and sulfonic acid are in closer proximity than on 'blended' mixed-mode resins (60-70% recovery).

Additional Publication Details

Publication type:
Conference Paper
Publication Subtype:
Conference Paper
Title:
Application of mixed-mode, solid-phase extraction in environmental and clinical chemistry. Combining hydrogen-bonding, cation-exchange and Van der Waals interactions
DOI:
10.1016/0021-9673(93)80349-D
Volume
629
Issue:
1
Year Published:
1993
Language:
English
Larger Work Title:
Journal of Chromatography
First page:
11
Last page:
21
Number of Pages:
11