Application of mixed-mode, solid-phase extraction in environmental and clinical chemistry. Combining hydrogen-bonding, cation-exchange and Van der Waals interactions

Mills, M. S.; Thurman, E. M.; Pedersen, M. J.

Abstract:

Silica- and styrene-divinylbenzene-based mixed-mode resins that contain C8, C18 and sulphonated cation-exchange groups were compared for their efficiency in isolation of neutral triazine compounds from water and of the basic drug, benzoylecgonine, from urine. The triazine compounds were isolated by a combination of Van der Waals and hydrogen-bonding interactions, and benzoylecgonine was isolated by Van der Waals interactions and cation exchange. All analytes were eluted with a polar organic solvent contaning 2% ammonium hydroxide. Larger recoveries (95%) were achieved on copolymerized mixed-mode resins where C18 and sulfonic acid are in closer proximity than on ‘blended‘ mixed-mode resins (60-70% recovery).

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Conference Paper

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70018255

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Mills, M. S.; Thurman, E. M.; Pedersen, M. J.

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English

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Journal of Chromatography

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Application of mixed-mode, solid-phase extraction in environmental and clinical chemistry. Combining hydrogen-bonding, cation-exchange and Van der Waals interactions; 1993; Conference Paper; Journal of Chromatography; Mills, M. S.; Thurman, E. M.; Pedersen, M. J.