| Abstract: | The pharmacokinetics of benzocaine during bath exposures at 1 mg/L were determined in rainbow trout acclimated at 6 °C, 12 °C or 18 °C for at least 1 month. Individual fish were exposed to benzocaine in a recirculating system for 4 h and pharmacokinetic parameters were estimated in a unique manner from the concentration of benzocaine in the bath water vs. time curve. Elimination from plasma was also determined after the 4 h exposure. The uptake clearance and metabolic clearance increased with increased acclimatization temperatures (uptake clearance 581 ± 179 mL/min/kg at 6 °C and 1154 ± 447 mL/ min/kg at 18 °C; metabolic clearance 15.2 ± 4.1 mL/min/kg at 6 °C and 22.3 ± 4.2 mL/min/kg at 18 °C). The apparent volume of distribution had a trend for increasing with temperature that was not significant at the 5% level (2369 ± 678 mL/kg at 6 °C to 3260 ± 1182 mL/kg at 18 °C). The elimination half-life of benzocaine in plasma was variable and did not differ significantly with temperature (60.8 ± 30.3 min at 6 °C to 35.9 ± 13.0 min at 12 °C). Elimination of benzocaine from rainbow trout is relatively rapid and even more rapid at higher acclimatization temperatures based on calculated metabolic clearances and measured plasma concentrations, but was not evident by measurement of terminal plasma half-lifes. |
| Genre: | Article |
| ProdID: | 70020080 |
| Citation Author: | Stehly, G. R.; Meinertz, J. R.; Gingerich, W. H. |
| Citation Contributing Office: | Upper Mississippi Science Center |
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| Citation End Page: | 127 |
| Citation Issue: | 2 |
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| Citation Language: | English |
| Citation Larger Work Title: | Journal of Veterinary Pharmacology and Therapeutics |
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| Citation Number Of Pages: | 7 |
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| Citation Phsyical Description: | 7 p. |
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| Citation Publisher: | Wiley |
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| Citation Search Results Text: | Effect of temperature on the pharmacokinetics of benzocaine in rainbow trout (Oncorhynchus mykiss) after bath exposures; 1998; Article; Journal; Journal of Veterinary Pharmacology and Therapeutics; Stehly, G. R.; Meinertz, J. R.; Gingerich, W. H. |
| Citation Start Page: | 121 |
| Citation Volume: | 21 |
| Citation Year: | 1998 |
| Type: | citation/reference |
| Text: | Effect of temperature on the pharmacokinetics of benzocaine in rainbow trout (Oncorhynchus mykiss) after bath exposures; 1998; Article; Journal; Journal of Veterinary Pharmacology and Therapeutics; Stehly, G. R.; Meinertz, J. R.; Gingerich, W. H. |
| URL (THUMBNAIL): | http://pubs.er.usgs.gov/thumbnails/outside_thumb.jpg |
| URL (DIGITAL OBJECT IDENTIFIER): | http://dx.doi.org/10.1046/j.1365-2885.1998.00109.x |
| Date Other: | Thu, 1 Jan 1998 00:00 -0600 |
| Publisher: | Wiley |
