The Eocene (42 to 41 Ma) El Salvador porphyry copper deposit in the Indio Muerto district, northern Chile (26° 15′ S Lat.), formerly thought to have formed at the culmination of a 9-m.y. period of episodic magmatism, is shown by new mapping, U-Pb and K-Ar geochronology, and petrologic data to have formed during the younger of two distinct but superposed magmatic events-a Paleocene (∼63 to 58 Ma) and an Eocene (44 to 41 Ma) event. In the district, high-K Paleocene volcano-plutonic activity was characterized by a variety of eruptive styles and magmatic compositions, including a collapse caldera associated with explosive rhyolitic magmatism (El Salvador trapdoor caldera), a post-collapse rhyolite dome field (Cerro Indio Muerto), and andesitic-trachyandesitic stratovolcanos (Kilometro Catorce-Los Amarillos sequence). Pre-caldera basement faults were reactivated during Paleocene volcanism as part of the collapse margin of the caldera. Beneath Cerro Indio Muerto, where the porphyry Cu deposit subsequently formed, the intersection of two major basement faults and the NNE-striking rotational axis of tilted ignimbrites of the Paleocene El Salvador caldera localized emplacement of post-collapse rhyolite domes and peripheral dikes and sills. Subsequent Eocene rhyolitic and granodioritic-dacitic porphyries intruded ~14 m.y. after cessation of Paleocene magmatism along the same NNE-striking structural belt through Cerro Indio Muerto as did the post-collapse Paleocene rhyolite domes. Eocene plutonism over a 3-m.y. period was contemporaneous with NW-SE-directed shortening associated with regional sinistral transpression along the Sierra Castillo fault, lying ∼10 km to the east. Older Eocene rhyolitic porphyries in the Indio Muerto district were emplaced between 44 and 43 Ma, and have a small uneconomic Cu center associated with a porphyry at Old Camp. The oldest granodioritic-dacitic porphyries also were emplaced at ∼44 to 43 Ma, but their petrogenetic relation to the rhyolitic porphyries and younger granodioritic-dacitic porphyries in the district is unclear. The main porphyry Cu-Mo-related granodioritic-dacitic stocks in Quebrada Turquesa on Cerro Indio Muerto intruded, cooled, and were mineralized within ∼1 m.y. between 42 and 41 Ma. Volumetrically minor late- to post-mineral porphyries are slightly more mafic than earlier granodioritic-dacitic porphyries, a compositional trend possibly repeated on several scales and more than once over the 3-million-year Eocene magmatic history of the Indio Muerto district. This compositional trend requires either addition of basaltic material into an open-system silicic magma chamber or tapping of progressively deeper levels of a vertically zoned magma chamber. Eocene porphyry magmas were more hydrous and their residual source mineralogy richer in garnet than the relatively anhydrous Paleocene rocks, whose source was rich in pyroxene. The presence of inherited zircons in Paleocene and Eocene rocks requires interaction with crustal rocks of Paleozoic and/or Proterozoic age.