Serum cortisol concentrations, plasma glucose concentrations, plasma lactate concentrations, and plasma osmolalities increased in red drum Sciaenops ocellatus (26.0-65.5 cm total length) during angling in estuarine waters (17-33 g/L salinity, 21-31??C). Angling time varied from as fast as possible (10 s) to the point when fish ceased resisting (up to 350 s). The increases in the physiological characteristics were similar in wild and hatchery-produced fish. This study indicates that hatchery-produced red drum may be used in catch-and-release studies to simulate the responses of wild fish.