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Protection of rainbow trout against infectious hematopoietic necrosis virus four days after specific or semi-specific DNA vaccination

Vaccine

By:
, , , , , , and
DOI: 10.1016/S0264-410X(01)00113-X

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Abstract

A DNA vaccine against a fish rhabdovirus, infectious hematopoietic necrosis virus (IHNV), was shown to provide significant protection as soon as 4 d after intramuscular vaccination in 2 g rainbow trout (Oncorhynchus mykiss) held at 15??C. Nearly complete protection was also observed at later time points (7, 14, and 28 d) using a standardized waterborne challenge model. In a test of the specificity of this early protection, immunization of rainbow trout with a DNA vaccine against another fish rhabdovirus, viral hemorrhagic septicemia virus, provided a significant level of cross-protection against IHNV challenge for a transient period of time, whereas a rabies virus DNA vaccine was not protective. This indication of distinct early and late protective mechanisms was not dependent on DNA vaccine doses from 0.1 to 2.5 ??g. ?? 2001 Elsevier Science Ltd.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Protection of rainbow trout against infectious hematopoietic necrosis virus four days after specific or semi-specific DNA vaccination
Series title:
Vaccine
DOI:
10.1016/S0264-410X(01)00113-X
Volume
19
Issue:
28-29
Year Published:
2001
Language:
English
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Vaccine
First page:
4011
Last page:
4019
Number of Pages:
9