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Relation of concentration and exposure time to the efficacy of niclosamide against larval sea lampreys (Petromyzon marinus)

Journal of Great Lakes Research

By:
, , and
DOI: 10.1016/S0380-1330(03)70510-3

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Abstract

The efficacy of 2', 5-dichloro-4'-nitrosalicylanilide (niclosamide) at various concentrations and exposure times was tested against free-swimming larval sea lampreys (Petromyzon marinus) at 72°C and 17°C in Lake Huron water. Concentrations of niclosamide in test solutions ranged from 0.46 to 4.7 mg/L with pH 7.8 to 8.3, total alkalinity 78 to 88 mg/L as CaCO3, and total hardness 95 to 105 mg/L as CaCO3. In each test, six groups of larvae were exposed to a single concentration of niclosamide for times ranging from 30 s to 30 min. Exposure time was treated as the dose and, for each concentration tested, the exposure time necessary to kill 50 and 99.9% of larvae (ET50 and ET99.9) was determined. Linear regressions of the log10-transformed ET50 and ET99.9 on the log10- transformed niclosamide concentrations were significant at both temperatures with r2 ranging from 0.94 to 0.98. The predicted ET50 ranged from 58 sec to 21.7 min and the ET99.9 ranged from 2.5 to 43.5 min across the concentrations and temperatures tested. Niclosamide required a significantly longer time to kill larvae at 12°C than at 17°C.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Relation of concentration and exposure time to the efficacy of niclosamide against larval sea lampreys (Petromyzon marinus)
Series title:
Journal of Great Lakes Research
DOI:
10.1016/S0380-1330(03)70510-3
Volume
29
Issue:
SUPPL. 1
Year Published:
2003
Language:
English
Publisher:
Elsevier
Publisher location:
Amsterdam, Netherlands
Contributing office(s):
Great Lakes Science Center
Description:
7 p.
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Journal of Great Lakes Research
First page:
493
Last page:
499
Number of Pages:
7