The eastern syntaxis of the Himalayas is expressed in the crust as a pronounced southward bend in the orogen. The change in strike of geologic features coincides with the high topography of the Namche Barwa region, the exposure of granulite-grade metamorphic rocks, and a 180-degree bend in the Yalu Tsangpo. We have conducted a geochronologic and geochemical investigation of several suites of granitoids collected from the Namche Barwa massif and subjacent terranes of southeastern Tibet, ranging from cm-scale dikes and sills to larger, outcrop-scale intrusions. U-Pb SHRIMP-RG zircon ages establish at least five magmatic episodes: ∼400 to 500 Ma, ∼120 Ma, 40 to 70 Ma, 18 to 25 Ma, and 3 to 10 Ma. These episodes broadly correlate to spatial patterns in sample localities, as follows: 400 to 500 Ma ages occur in zircon cores collected from within the massif proper; ∼120 Ma granites, related to early Gangdese arc plutonism, are primarily located northeast of Namche Barwa; later (40-70 Ma) Gangdese activity is expressed in granites west of Namche Barwa. 18 to 25 Ma granites occur both along the suture zone west of Gyala Peri, and directly north of Namche Barwa along the area of the Jiali fault zone, and are attributed both to shearing within the Jiali fault zone and to an early Miocene Gangdese Thrust event. Exceptionally young (<10 Ma) zircon ages are clustered near the core of the massif, along the Yalu Tsangpo gorge. Trace-element geochemical data indicates the presence of both fluid-present and fluid absent melts, with a fluid-absent (decompression) melting regime dominating near the core of Namche Barwa.